Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC022
Sex MALE
Dominant hand LEFT
Test date and time 2022-05-06 12:24
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250 mg 4x1/2 caps Madopar HBS a 125 mg 2 uvece

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 34 individuals with a value less than 0.68 were subsequently diagnosed with PD. That is, 80.95% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.68 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 26, 'TN': 21, 'TP': 16, 'FP': 9}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 20, 'TN': 17, 'TP': 22, 'FP': 13}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 27, 'TN': 21, 'TP': 15, 'FP': 9}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 20, 'TN': 15, 'TP': 22, 'FP': 15}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 15.28
timePerCircleCoV 0.111379
timePerCircleSlope -0.000412502
meanError 1.09265
tremorFreq 6.44531
tremorRelPower 24.9849
tremorGyroAmpMean 0.0105469
tremorGyroAmpSlope 0.00153012
tremorGyroAmpCoV 0.386054
tremorCoordAmpMean 0.0214752
tremorCoordAmpSlope -0.000936208
tremorCoordAmpCoV 0.239979
tremorAccAmpMean 0.0233306
tremorAccAmpSlope 0.000166091
tremorAccAmpCoV 0.233276
tremorPcRelVar 0.584719
tremorPcX -0.430408
tremorPcY 0.902635

Circle Segment 1

Duration 15.84 s, Accuracy Estimate 1.267 (lower is better)

Circle Segment 2

Duration 14.36 s, Accuracy Estimate 0.821 (lower is better)

Circle Segment 3

Duration 17.28 s, Accuracy Estimate 0.837 (lower is better)

Circle Segment 4

Duration 13.36 s, Accuracy Estimate 0.917 (lower is better)

Circle Segment 5

Duration 13.64 s, Accuracy Estimate 0.916 (lower is better)

Circle Segment 6

Duration 18.68 s, Accuracy Estimate 1.175 (lower is better)

Circle Segment 7

Duration 14.48 s, Accuracy Estimate 0.861 (lower is better)

Circle Segment 8

Duration 14.28 s, Accuracy Estimate 0.966 (lower is better)

Circle Segment 9

Duration 14.64 s, Accuracy Estimate 1.06 (lower is better)

Circle Segment 10

Duration 16.24 s, Accuracy Estimate 2.107 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 40.072
timePerSpiralCoV 0.110793
timePerSpiralSlope -0.00402911
meanError 1.5802
tremorFreq 6.34766
tremorRelPower 27.951
tremorGyroAmpMean 0.0119717
tremorGyroAmpSlope 0.000249764
tremorGyroAmpCoV 0.366286
tremorCoordAmpMean 0.0252605
tremorCoordAmpSlope 7.50315e-07
tremorCoordAmpCoV 0.367806
tremorAccAmpMean 0.0452325
tremorAccAmpSlope 9.64809e-05
tremorAccAmpCoV 0.0824561
tremorPcRelVar 0.623441
tremorPcX 0.653049
tremorPcY 0.757316

Spiral Segment 1

Duration 47.64 s, Accuracy Estimate 1.721 (lower is better)

Spiral Segment 2

Duration 43.36 s, Accuracy Estimate 1.431 (lower is better)

Spiral Segment 3

Duration 36.6 s, Accuracy Estimate 1.684 (lower is better)

Spiral Segment 4

Duration 35.48 s, Accuracy Estimate 1.522 (lower is better)

Spiral Segment 5

Duration 36.92 s, Accuracy Estimate 1.588 (lower is better)

Spiral Segment 6

Duration 38.0 s, Accuracy Estimate 1.569 (lower is better)

Spiral Segment 7

Duration 39.24 s, Accuracy Estimate 1.505 (lower is better)

Spiral Segment 8

Duration 35.6 s, Accuracy Estimate 1.46 (lower is better)

Spiral Segment 9

Duration 46.32 s, Accuracy Estimate 1.533 (lower is better)

Spiral Segment 10

Duration 41.56 s, Accuracy Estimate 1.788 (lower is better)

Elel

eDurationMean 0.683155
eDurationStd 0.174904
eDurationStdnorm 0.256024
eDurationMedian 0.655017
eDurationQuartdelta 0.177505
eDurationQuartdeltanorm 0.270992
eDurationKurt 8.16599
eDurationTrenddiff 0.0700018
eDurationTrendratio 1.10687
eWidthMean 4.76525
eWidthStd 1.54151
eWidthStdnorm 0.32349
eWidthMedian 4.446
eWidthQuartdelta 1.68649
eWidthQuartdeltanorm 0.379327
eWidthKurt 5.18267
eWidthTrenddiff 0.456717
eWidthTrendratio 1.1055
eHeightMean 9.52523
eHeightStd 3.5857
eHeightStdnorm 0.376442
eHeightMedian 10.53
eHeightQuartdelta 4.33157
eHeightQuartdeltanorm 0.411355
eHeightKurt 2.52212
eHeightTrenddiff -1.053
eHeightTrendratio 0.905263
eAspectMean 0.591239
eAspectStd 0.334037
eAspectStdnorm 0.564979
eAspectMedian 0.479167
eAspectQuartdelta 0.220457
eAspectQuartdeltanorm 0.460083
eAspectKurt 6.01665
eAspectTrenddiff 0.0671795
eAspectTrendratio 1.15995
eSlantMean -0.180623
eSlantStd 0.306947
eSlantStdnorm -1.69938
eSlantMedian -0.183517
eSlantQuartdelta 0.29445
eSlantQuartdeltanorm -1.60449
eSlantKurt 6.06092
eSlantTrenddiff -0.0185652
eRtopMean 0.592584
eRtopStd 0.146255
eRtopStdnorm 0.246808
eRtopMedian 0.615312
eRtopQuartdelta 0.16993
eRtopQuartdeltanorm 0.276169
eRtopKurt 2.44264
eRtopTrenddiff -0.0415058
eRbotMean 1.0261
eRbotStd 0.482102
eRbotStdnorm 0.469839
eRbotMedian 0.994148
eRbotQuartdelta 0.716982
eRbotQuartdeltanorm 0.721202
eRbotKurt 2.41456
eRbotTrenddiff -0.273801
eRrightMean 0.661303
eRrightStd 0.273167
eRrightStdnorm 0.413074
eRrightMedian 0.761533
eRrightQuartdelta 0.197664
eRrightQuartdeltanorm 0.259561
eRrightKurt 9.29503
eRrightTrenddiff -0.113359
eRleftMean 0.514878
eRleftStd 0.148233
eRleftStdnorm 0.2879
eRleftMedian 0.53714
eRleftQuartdelta 0.211793
eRleftQuartdeltanorm 0.394299
eRleftKurt 2.79031
eRleftTrenddiff 0.000672725
lDurationMean 0.837196
lDurationStd 0.143413
lDurationStdnorm 0.171302
lDurationMedian 0.802521
lDurationQuartdelta 0.130003
lDurationQuartdeltanorm 0.161994
lDurationKurt 6.09423
lDurationTrenddiff 0.0300008
lDurationTrendratio 1.03797
lWidthMean 5.65373
lWidthStd 1.54824
lWidthStdnorm 0.273845
lWidthMedian 5.4405
lWidthQuartdelta 2.106
lWidthQuartdeltanorm 0.387097
lWidthKurt 4.88934
lWidthTrenddiff 0.227776
lWidthTrendratio 1.04232
lHeightMean 23.713
lHeightStd 3.05525
lHeightStdnorm 0.128843
lHeightMedian 23.517
lHeightQuartdelta 3.861
lHeightQuartdeltanorm 0.164179
lHeightKurt 4.55889
lHeightTrenddiff -0.702
lHeightTrendratio 0.971014
lAspectMean 0.239
lAspectStd 0.0601193
lAspectStdnorm 0.251545
lAspectMedian 0.231401
lAspectQuartdelta 0.0627505
lAspectQuartdeltanorm 0.271176
lAspectKurt 8.4174
lAspectTrenddiff 0.00312554
lAspectTrendratio 1.0136
lSlantMean -0.0986595
lSlantStd 0.0944749
lSlantStdnorm -0.957585
lSlantMedian -0.083964
lSlantQuartdelta 0.103681
lSlantQuartdeltanorm -1.23483
lSlantKurt 4.17394
lSlantTrenddiff 0.00941029
lRtopMean 0.588405
lRtopStd 0.13777
lRtopStdnorm 0.234142
lRtopMedian 0.60912
lRtopQuartdelta 0.163386
lRtopQuartdeltanorm 0.268233
lRtopKurt 3.3967
lRtopTrenddiff -0.0405113
lRbotMean 1.02465
lRbotStd 0.287532
lRbotStdnorm 0.280614
lRbotMedian 1.0149
lRbotQuartdelta 0.342622
lRbotQuartdeltanorm 0.337594
lRbotKurt 2.28458
lRbotTrenddiff -0.0602234
lRrightMean 0.762938
lRrightStd 0.113638
lRrightStdnorm 0.148948
lRrightMedian 0.780568
lRrightQuartdelta 0.118717
lRrightQuartdeltanorm 0.152091
lRrightKurt 4.70278
lRrightTrenddiff -0.0366578
lRleftMean 0.49522
lRleftStd 0.16152
lRleftStdnorm 0.326158
lRleftMedian 0.477898
lRleftQuartdelta 0.233771
lRleftQuartdeltanorm 0.489164
lRleftKurt 2.11193
lRleftTrenddiff 0.143432

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.967389
sumTouchScores 20.3152
meanMovementTime 0.90925
numTouches 21
undershootPercentage 0
overshootPercentage 9.52381

FITTS Long Modified

meanTouchScore 0.762768
sumTouchScores 10.6787
meanMovementTime 1.43154
numTouches 14
undershootPercentage 0
overshootPercentage 57.1429

fitts_long data not in signals file.

ZigZag

numZigzags 5
timePerZigzagMean 37.44
timePerZigzagCoV 0.116847
timePerZigzagSlope -0.0667735
meanError 1.91869
tremorFreq 6.05469
tremorRelPower 29.967
tremorGyroAmpMean 0.0191395
tremorGyroAmpSlope 0.000297455
tremorGyroAmpCoV 0.399972
tremorCoordAmpMean 0.0325011
tremorCoordAmpSlope 0.00151105
tremorCoordAmpCoV 0.393165
tremorAccAmpMean 0.0346922
tremorAccAmpSlope 0.00079116
tremorAccAmpCoV 0.214454
tremorPcRelVar 0.783085
tremorPcX -0.213069
tremorPcY -0.977037

ZigZag Segment 1

Duration 40.8 s, Accuracy Estimate 1.675 (lower is better)

ZigZag Segment 2

Duration 40.24 s, Accuracy Estimate 1.843 (lower is better)

ZigZag Segment 3

Duration 40.52 s, Accuracy Estimate 1.731 (lower is better)

ZigZag Segment 4

Duration 34.44 s, Accuracy Estimate 2.302 (lower is better)

ZigZag Segment 5

Duration 31.2 s, Accuracy Estimate 2.043 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 22.328
timePerZigzagCoV 0.103172
timePerZigzagSlope -0.0395915
zigzagHeightMean 69.2961
zigzagHeightCoV 0.0309343
zigzagHeightSlope 0.00565736
meanError 0.0352272
tremorFreq 6.34766
tremorRelPower 27.7335
tremorGyroAmpMean 0.0178317
tremorGyroAmpSlope 0.00182143
tremorGyroAmpCoV 0.347404
tremorCoordAmpMean 0.0415787
tremorCoordAmpSlope 0.00163039
tremorCoordAmpCoV 0.373431
tremorAccAmpMean 0.0533001
tremorAccAmpSlope 0.000504018
tremorAccAmpCoV 0.183316
tremorPcRelVar 0.787998
tremorPcX 0.15802
tremorPcY -0.987436

ZigZag Offset Segment 1

Duration 25.8 s, Accuracy Estimate 0.03 (lower is better)

ZigZag Offset Segment 2

Duration 22.8 s, Accuracy Estimate 0.031 (lower is better)

ZigZag Offset Segment 3

Duration 19.44 s, Accuracy Estimate 0.028 (lower is better)

ZigZag Offset Segment 4

Duration 21.64 s, Accuracy Estimate 0.029 (lower is better)

ZigZag Offset Segment 5

Duration 21.96 s, Accuracy Estimate 0.057 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.47}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.68}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.10670533613694477}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8870629168397659}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.7740070014563843}